Foscarnet: Difference between revisions
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*Active against all [[human herpesviruses]] |
*Active against all [[human herpesviruses]] |
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+ | ===Pharmacokinetics and Pharmacodynamics=== |
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+ | *CSF penetration 66% of serum levels |
| − | == |
+ | ==Dosing== |
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+ | ===Pediatric Dosing=== |
| − | * |
+ | *Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h |
| − | * |
+ | *Maintenance: foscarnet 90 to 120 mg/kg IV q24h |
| − | == |
+ | ==Safety== |
| + | *Nephrotoxicity, usually reversible |
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| − | * Nephrotoxic |
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| − | * |
+ | *Electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]] |
| + | *Seizures |
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| + | *Genital ulcers |
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| + | *Anemia |
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| + | *Nausea |
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[[Category:Antivirals]] |
[[Category:Antivirals]] |
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Revision as of 19:16, 14 September 2020
Background
- Inhibits DNA polymerase in human herpesviruses
- Indications: CMV after hematopoietic stem cell transplantation, CMV after solid organ transplantation, Cytomegalovirus, Herpes simplex virus, Herpesviridae, Post-transplant acute limbic encephalitis
Spectrum of Activity
- Active against all human herpesviruses
Pharmacokinetics and Pharmacodynamics
- CSF penetration 66% of serum levels
Dosing
Pediatric Dosing
- Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
- Maintenance: foscarnet 90 to 120 mg/kg IV q24h
Safety
- Nephrotoxicity, usually reversible
- Electrolyte abnormalities, including hypocalcemia, hypophosphatemia, hyperphosphatemia, hypomagnesemia, and hypokalemia
- Seizures
- Genital ulcers
- Anemia
- Nausea
References
- ^ Dushyantha T. Jayaweera. Minimising the Dosage-Limiting Toxicities of Foscarnet Induction Therapy. Drug Safety. 1997;16(4):258-266. doi:10.2165/00002018-199716040-00003.
