Foscarnet: Difference between revisions
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+ | ==Background== |
*Inhibits DNA polymerase in [[human herpesviruses]] |
*Inhibits DNA polymerase in [[human herpesviruses]] |
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*Indications: {{#ask: [[Is treated by::foscarnet]] | default=none}} |
*Indications: {{#ask: [[Is treated by::foscarnet]] | default=none}} |
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| − | === |
+ | ===Spectrum of Activity=== |
| − | * |
+ | *Active against all [[human herpesviruses]] |
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| + | === Pharmacokinetics and Pharmacodynamics === |
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| + | * CSF penetration 66% of serum levels |
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| + | == Dosing == |
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| + | === Pediatric Dosing === |
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| + | * Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h |
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| + | * Maintenance: foscarnet 90 to 120 mg/kg IV q24h |
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| + | == Safety == |
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| + | * Nephrotoxic |
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| + | * Causes electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]] |
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[[Category:Antivirals]] |
[[Category:Antivirals]] |
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Revision as of 21:20, 11 September 2020
Background
- Inhibits DNA polymerase in human herpesviruses
- Indications: CMV after hematopoietic stem cell transplantation, CMV after solid organ transplantation, Cytomegalovirus, Herpes simplex virus, Herpesviridae, Post-transplant acute limbic encephalitis
Spectrum of Activity
- Active against all human herpesviruses
Pharmacokinetics and Pharmacodynamics
- CSF penetration 66% of serum levels
Dosing
Pediatric Dosing
- Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
- Maintenance: foscarnet 90 to 120 mg/kg IV q24h
Safety
- Nephrotoxic
- Causes electrolyte abnormalities, including hypocalcemia, hypophosphatemia, hyperphosphatemia, hypomagnesemia, and hypokalemia
References
- ^ Dushyantha T. Jayaweera. Minimising the Dosage-Limiting Toxicities of Foscarnet Induction Therapy. Drug Safety. 1997;16(4):258-266. doi:10.2165/00002018-199716040-00003.
