Fluconazole: Difference between revisions
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*Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida'' |
*Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida'' |
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| − | === |
+ | ===Pharmacokinetics and Pharmacodynamics=== |
| − | * |
+ | *Good oral bioavailability |
| − | * |
+ | *Good CNS penetration |
| − | * |
+ | *Fungistatic |
| + | *Efficacy predicted by AUC/MIC ratio |
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| − | * |
+ | *Susceptibility breakpoints for [[Candida albicans]] are: |
| − | ** Susceptible MIC ≤2 |
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| − | ** |
+ | **Susceptible MIC ≤2 |
| − | ** |
+ | **Susceptible dose-dependent MIC 4 |
| + | **Resistant MIC ≥8 |
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==Monitoring== |
==Monitoring== |
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Revision as of 12:16, 21 August 2020
Background
- Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida
Pharmacokinetics and Pharmacodynamics
- Good oral bioavailability
- Good CNS penetration
- Fungistatic
- Efficacy predicted by AUC/MIC ratio
- Susceptibility breakpoints for Candida albicans are:
- Susceptible MIC ≤2
- Susceptible dose-dependent MIC 4
- Resistant MIC ≥8
Monitoring
- ECG for QT prolongation
- Liver enzymes for hepatitis
Adverse Drug Reactions
- Best side effect profiles of the antifungals
- Before starting, check:
- Liver enzymes as baseline (hepatitis)
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
- Beware drug-drug interactions, especially with new DOACs
