Fluconazole: Difference between revisions
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| + | ==Background== |
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| − | == Classification == |
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+ | *Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of ''Candida'' |
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| − | == Indications == |
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| − | * Fungal infections |
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| + | * Fungistatic |
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| + | * Susceptibility breakpoints for [[Candida albicans]] are: |
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| + | ** Susceptible MIC ≤2 |
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| + | ** Susceptible dose-dependent MIC 4 |
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| + | ** Resistant MIC ≥8 |
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| − | == |
+ | ==Monitoring== |
| − | * |
+ | *ECG for QT prolongation |
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+ | *Liver enzymes for hepatitis |
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| + | **EKG ([[Adverse drug reaction::QTc prolongation]]) |
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| − | * |
+ | *Beware [[Adverse drug reaction::drug-drug interactions]], especially with new DOACs |
| − | * Beware [[Adverse drug reaction::drug-drug interactions]], especially with new DOACs |
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[[Category:Antifungals]] |
[[Category:Antifungals]] |
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Revision as of 12:16, 21 August 2020
Background
- Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida
Pharmacokinetics and Pharmacodynamics
- Good oral bioavailability
- Good CNS penetration
- Fungistatic
- Susceptibility breakpoints for Candida albicans are:
- Susceptible MIC ≤2
- Susceptible dose-dependent MIC 4
- Resistant MIC ≥8
Monitoring
- ECG for QT prolongation
- Liver enzymes for hepatitis
Adverse Drug Reactions
- Best side effect profiles of the antifungals
- Before starting, check:
- Liver enzymes as baseline (hepatitis)
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
- Beware drug-drug interactions, especially with new DOACs
