Duffy-null associated neutrophil count
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Revision as of 12:29, 2 November 2022 by Aidan (talk | contribs) (Created page with "== Background == * Previously known as benign ethnic neutropenia * Polymorphisms in ACKR1 gene, which encodes Duffy antigen receptor for chemokines (DARC) * The mutations lead to neutrophils leaving circulation for tissue, resulting in lower peripheral blood neutrophil counts * The gene mutation is present in about 60 to 70% of people with African ancestry, and may have evolved to impair entry of Plasmodium vivax into RBCs * About 10% of people with DANC will have a...")
Background
- Previously known as benign ethnic neutropenia
- Polymorphisms in ACKR1 gene, which encodes Duffy antigen receptor for chemokines (DARC)
- The mutations lead to neutrophils leaving circulation for tissue, resulting in lower peripheral blood neutrophil counts
- The gene mutation is present in about 60 to 70% of people with African ancestry, and may have evolved to impair entry of Plasmodium vivax into RBCs
- About 10% of people with DANC will have an ANC less than 1.5
