Drug reaction with eosinophilia and systemic symptoms: Difference between revisions

Revision as of 10:07, 2 August 2020

Characterized by fever, facial edema, maculopapular rash, lymphadenopathy, eosinophilia, atypical lymphocytosis, and multiorgan dysfunction
- Includes hepatitis, glomerulonephritis, arthritis, pneumonitis, and carditis
Typical onset 2 to 8 weeks after starting medication
Commonly-associated medications:
- Antibiotics, including vancomycin
  - Vancomycin-associated DRESS is more common in European descendants, with the HLA-A*32:01 allele
- Antiepileptic medications
- Allopurinol
High mortality around 10%

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+== Background ==
-* T-cell mediated hypersensitivity reaction
-* Characterized by fever, facial edema, maculopapular rash, lymphadenopathy, eosinophilia, atypical lymphocytosis, and multiorgan dysfunction
+*T-cell mediated hypersensitivity reaction
-** Includes hepatitis, glomerulonephritis, arthritis, pneumonitis, and carditis
-* Typical onset 2 to 8 weeks after starting medication
+== Clinical Manifestations ==
-* Commonly-associated medications:
-** Antibiotics, including [[vancomycin]]
+*Characterized by [[fever]], facial edema, [[maculopapular rash]], [[lymphadenopathy]], [[eosinophilia]], [[atypical lymphocytosis]], and multiorgan dysfunction
-*** Vancomycin-associated DRESS is more common in European descendents, with the HLA-A*32:01 allele
+**Includes [[hepatitis]], [[glomerulonephritis]], [[arthritis]], [[pneumonitis]], and [[carditis]]
-** Antiepileptic medications
+*Typical onset 2 to 8 weeks after starting medication
-** Allopurinol
+*Commonly-associated medications:
-* High mortality around 10%
+**Antibiotics, including [[vancomycin]]
+***[[Vancomycin]]-associated DRESS is more common in European descendants, with the HLA-A*32:01 allele
+**[[Antiepileptic]] medications
+**[[Allopurinol]]
+*High mortality around 10%
 [[Category:Adverse events]]