Dosing of antimicrobials in obesity: Difference between revisions

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| 2 g IV q4h
 
| 2 g IV q4h
 
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|-
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| [[Nafcillin]]
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|
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| 2 g IV q4h
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| No data
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|-
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| [[Piperacillin-tazobactam]]
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| 4.5 g IV q6-8h
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| Prolonged infusion
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| 18 g daily
 
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| 2-3 g IV q6-8h
 
| 2-3 g IV q6-8h
 
| No data; 12 g daily
 
| No data; 12 g daily
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|-
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| [[Cephalexin]]
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| 500-1000 g PO qid
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| 1000 g PO qid
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| No data
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|-
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| [[Cefipime]]
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| 2 g IV q8h
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| 2 g IV q8h prolonged infusion
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| 2 g IV q8h prolonged infusion
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|-
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| [[Ceftazidime]]
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| 2 g IV q8h
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| 2 g IV q8h prolonged infusion
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| 2 g IV q8h prolonged infusion
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|-
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| [[Ceftazidime-avibactam]]
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|
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| Usual dose
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|
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|-
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| [[Ceftolozane-tazobactam]]
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|
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| Usual dose
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|
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|}
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=== Carbapenems ===
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{| class="wikitable"
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! Drug !! Usual Dose !! Obesity !! Max dose
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|}
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== Quinolones ==
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{| class="wikitable"
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! Drug !! Usual Dose !! Obesity !! Max dose
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|}
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== Quinolones ==
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{| class="wikitable"
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! Drug !! Usual Dose !! Obesity !! Max dose
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|}
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== Macrolides ==
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{| class="wikitable"
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! Drug !! Usual Dose !! Obesity !! Max dose
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|}
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== Tetracyclines ==
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{| class="wikitable"
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! Drug !! Usual Dose !! Obesity !! Max dose
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|}
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== Others ==
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{| class="wikitable"
  +
! Drug !! Usual Dose !! Obesity !! Max dose
 
|}
 
|}
   

Revision as of 12:03, 9 December 2019

Calculating Body Weight

Statistic Equation (Male) Equation (Female) Notes
Body mass index (BMI) (kg/m2) weight, kg / (height, m)2
Body surface area (BSA) (m2) (height, cm × weight, kg / 3600)1/2
Ideal body weight (IBW) (kg) 50 + 2.3 × (inches over 5 ft) 45.5 + 2.3 × (inches over 5 ft)
Adjusted body weight (ABW) (kg) IBW + C × (TBW - IBW) C = 0.3 to 0.4
Lean body weight (LBW) (kg) 9270 × TBW / 6680 + 216 x BMI 9270 × TBW / 8780 + 244 x BMI
Fat-free weight (FFW) (kg) 0.00139 × (height, cm)2 - 0.0801 × R + 0.187 × TBW + 39.83 0.00151 × (height, cm)2 - 0.0344 × R + 0.14 × TBW - (0.158 × age) + 20.387 R = resistance

Antibiotics

Penicillins

Drug Usual Dose Obesity Max dose
Amoxicillin 1 g PO q8h No data
Ampicillin 2 g IV q4h
Nafcillin 2 g IV q4h No data
Piperacillin-tazobactam 4.5 g IV q6-8h Prolonged infusion 18 g daily

Cephalosporins

Drug Usual Dose Obesity Max dose
Cefazolin 1-2 g IV q8h 2-3 g IV q6-8h No data; 12 g daily
Cephalexin 500-1000 g PO qid 1000 g PO qid No data
Cefipime 2 g IV q8h 2 g IV q8h prolonged infusion 2 g IV q8h prolonged infusion
Ceftazidime 2 g IV q8h 2 g IV q8h prolonged infusion 2 g IV q8h prolonged infusion
Ceftazidime-avibactam Usual dose
Ceftolozane-tazobactam Usual dose

Carbapenems

Drug Usual Dose Obesity Max dose

Quinolones

Drug Usual Dose Obesity Max dose

Quinolones

Drug Usual Dose Obesity Max dose

Macrolides

Drug Usual Dose Obesity Max dose

Tetracyclines

Drug Usual Dose Obesity Max dose

Others

Drug Usual Dose Obesity Max dose

Further Reading

  • Comprehensive Guidance for Antibiotic Dosing in Obese Adults. Pharmacotherapy. 2017;37(11):1415-1431. doi: 10.1002/phar.2023