Daptomycin: Difference between revisions

Revision as of 16:13, 30 August 2022

Distributes well into soft tissues and musculoskeletal system, as well as urine
- Poor CNS penetration1
- Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia
Bactericidal
Concentration-dependent, best predicted by AUC₂₄:MIC

Standard dose: 6 mg/kg IV q24h
High dose for severe infections, including MRSA bacteremia: 8 to 10 mg/kg IV q24h

GFR (mL/min)	Routine Dose	High Dose
>50	6 mg/kg IV q24h	8-10 mg/kg IV q24h
11-50		6-8 mg/kg IV q24h
≤10		8 mg/kg IV q48h
HD		8 mg/kg IV q48h, dosed after dialysis
CRRT		8 mg/kg IV q48h

^ S. Piva, Antonello Di Paolo, Laura Galeotti, Francesco Ceccherini, Francesco Cordoni, Liana Signorini, Tommaso Togni, Amedeo De Nicolò, Frank A. Rasulo, Nazzareno Fagoni, N. Latronico, Antonio D’Avolio. Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis. Neurocritical Care. 2019;31(1):116-124. doi:10.1007/s12028-018-0657-y.

@@ Line 15: / Line 15: @@
 *Concentration-dependent, best predicted by AUC<sub>24</sub>:MIC
+== Dosing ==
+* Standard dose: 6 mg/kg IV q24h
+* High dose for severe infections, including [[MRSA bacteremia]]: 8 to 10 mg/kg IV q24h
+=== Renal Dosing ===
+{| class="wikitable"
+!GFR (mL/min)
+!Routine Dose
+!High Dose
+|-
+|>50
+|6 mg/kg IV q24h
+|8-10 mg/kg IV q24h
+|-
+|11-50
+|
+|6-8 mg/kg IV q24h
+|-
+|≤10
+|
+|8 mg/kg IV q48h
+|-
+|HD
+|
+|8 mg/kg IV q48h, dosed after dialysis
+|-
+|CRRT
+|
+|8 mg/kg IV q48h
+|}
 [[Category:Cyclic lipopeptides]]