Daptomycin: Difference between revisions
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===Pharmacokinetics and Pharmacodynamics=== |
===Pharmacokinetics and Pharmacodynamics=== |
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*Distributes well into soft tissues and musculoskeletal system, as well as urine |
*Distributes well into soft tissues and musculoskeletal system, as well as urine |
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**Poor CNS penetration[[CiteRef::piva2019da]] |
**Poor CNS penetration[[CiteRef::piva2019da]] |
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**Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia |
**Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia |
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| + | *Concentration-dependent, best predicted by AUC<sub>24</sub>:MIC |
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[[Category:Cyclic lipopeptides]] |
[[Category:Cyclic lipopeptides]] |
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Revision as of 06:15, 28 September 2020
Background
- Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria
Mechanism of Action
- Mechanism of action is to depolarize the cell membrane
Pharmacokinetics and Pharmacodynamics
- Distributes well into soft tissues and musculoskeletal system, as well as urine
- Poor CNS penetration1
- Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia
- Bactericidal
- Concentration-dependent, best predicted by AUC24:MIC
