Daptomycin: Difference between revisions
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+ | ==Background== |
*Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria |
*Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria |
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+ | ===Mechanism of Action=== |
*Mechanism of action is to depolarize the cell membrane |
*Mechanism of action is to depolarize the cell membrane |
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+ | ===Pharmacokinetics and Pharmacodynamics=== |
*Bactericidal |
*Bactericidal |
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Revision as of 14:00, 21 September 2020
Background
- Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria
Mechanism of Action
- Mechanism of action is to depolarize the cell membrane
Pharmacokinetics and Pharmacodynamics
- Bactericidal
- Distributes well into soft tissues and musculoskeletal system, as well as urine
- Poor CNS penetration
- Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia
