Dapsone: Difference between revisions
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| + | ==Background== |
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| − | = Dapsone = |
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| − | * |
+ | *Diamino-diphenyl sulfone |
| − | == |
+ | ===Indications=== |
| − | * |
+ | *Second-line [[Pneumocystis jirovecii]] prophylaxis (CD4 <200) |
| − | * |
+ | *Along with [[rifampicin]] and [[clofazimine]] as multidrug therapy (MDT) for the treatment of ''[[Mycobacterium leprae]]'' |
| + | |||
| + | ==Dosing== |
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| + | |||
| + | *'''[[Dermatitis herpetiformis]]''' |
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| + | **Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose |
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| + | **Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days |
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| + | **After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks |
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| + | *'''[[Pneumocystis]] prophylaxis (primary or secondary)''' |
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| + | **100 mg PO once daily or in 2 divided doses as monotherapy |
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| + | **Continue until CD4 count >200 cells/mm3 for >3 months |
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| + | *'''[[Pneumocystis]] treatment:''' 100 mg PO once daily in combination with [[trimethoprim]] for 21 days |
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| + | |||
| + | ==Safety== |
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| + | |||
| + | *Check CBC, liver, and G6PD deficiency before starting |
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| + | |||
| + | [[Category:Antibiotics]] |
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Latest revision as of 09:15, 3 March 2021
Background
- Diamino-diphenyl sulfone
Indications
- Second-line Pneumocystis jirovecii prophylaxis (CD4 <200)
- Along with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae
Dosing
- Dermatitis herpetiformis
- Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
- Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
- After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
- Pneumocystis prophylaxis (primary or secondary)
- 100 mg PO once daily or in 2 divided doses as monotherapy
- Continue until CD4 count >200 cells/mm3 for >3 months
- Pneumocystis treatment: 100 mg PO once daily in combination with trimethoprim for 21 days
Safety
- Check CBC, liver, and G6PD deficiency before starting
