Dapsone: Difference between revisions
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+ | ==Background== |
*Diamino-diphenyl sulfone |
*Diamino-diphenyl sulfone |
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*Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae'' |
*Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of ''Mycobacterium leprae'' |
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+ | ==Dosing== |
| + | *'''Dermatitis herpetiformis:''' |
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| − | * '''Dermatitis herpetiformis:''' Start at 50 mg PO daily, increase to 300 mg daily, or higher to achieve full control, reduce to minimum maintenance dosage as soon as possible |
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| + | **Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose |
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| + | **Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days |
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| + | **After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks |
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| + | == Safety == |
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| + | * Check CBC, liver, and G6PD deficiency before starting |
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[[Category:Antibiotics]] |
[[Category:Antibiotics]] |
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Revision as of 09:14, 3 March 2021
Background
- Diamino-diphenyl sulfone
Indications
- Second-line PJP prophylaxis (CD4 <200)
- Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae
Dosing
- Dermatitis herpetiformis:
- Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
- Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
- After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
- PJP prophylaxis (primary or secondary):
- 100 mg PO once daily or in 2 divided doses as monotherapy
- Continue until CD4 count >200 cells/mm3 for >3 months
- PJP treatment: 100 mg PO once daily in combination with trimethoprim for 21 days
Safety
- Check CBC, liver, and G6PD deficiency before starting
