Cidofovir: Difference between revisions
From IDWiki
No edit summary |
(→â€)  |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
| − | == |
+ | ==Background== |
| + | *Acyclic nucleoside phosphonate that competes with cytosine nucleotides to inhibit viral DNA polymerase |
||
| − | *Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]] |
||
*Indications: {{#ask: [[Is treated by::cidofovir]] | default=none}} |
*Indications: {{#ask: [[Is treated by::cidofovir]] | default=none}} |
||
| − | === |
+ | ===Spectrum of Activity=== |
| − | * |
+ | *Active against essentially all [[:Category:DNA viruses|DNA viruses]], including polyomaviruses ([[BK virus]], [[JC virus]]), [[human papillomavirus]], [[adenovirus]], all of the [[human herpesviruses]], poxviruses (including [[monkeypox virus]] and [[variola virus]]) |
| − | * |
+ | *Not active against h[[Hepatitis B virus|epatitis B virus]] or [[:Category:RNA viruses|RNA viruses]] |
| − | === |
+ | ===Pharmacokinetics and Pharmacodynamics=== |
| − | * |
+ | *Unlike [[ganciclovir]], it does ''not'' need phosphorylation by UL97 |
| + | *Does not penetrate CSF |
||
| − | == |
+ | ==Dosing== |
*Should be given with [[probenecid]] 2 g IV prior to each dose |
*Should be given with [[probenecid]] 2 g IV prior to each dose |
||
| − | == |
+ | ==Safety== |
| − | *Major adverse effect is [[Adverse drug reaction:: |
+ | *Major adverse effect is dose-dependent, irreversible [[Adverse drug reaction::renal tubular necrosis]], which may be prevented by [[probenecid]] |
| + | **Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria) |
||
| + | *[[Neutropenia]] |
||
| + | *Acute [[iritis]] |
||
| − | [[Category: |
+ | [[Category:Acyclic nucleoside phosphonates]] |
Latest revision as of 19:14, 14 September 2020
Background
- Acyclic nucleoside phosphonate that competes with cytosine nucleotides to inhibit viral DNA polymerase
- Indications: Adenovirus, CMV after solid organ transplantation, Cytomegalovirus, Herpes simplex virus
Spectrum of Activity
- Active against essentially all DNA viruses, including polyomaviruses (BK virus, JC virus), human papillomavirus, adenovirus, all of the human herpesviruses, poxviruses (including monkeypox virus and variola virus)
- Not active against hepatitis B virus or RNA viruses
Pharmacokinetics and Pharmacodynamics
- Unlike ganciclovir, it does not need phosphorylation by UL97
- Does not penetrate CSF
Dosing
- Should be given with probenecid 2 g IV prior to each dose
Safety
- Major adverse effect is dose-dependent, irreversible renal tubular necrosis, which may be prevented by probenecid
- Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)
- Neutropenia
- Acute iritis
