Cidofovir: Difference between revisions
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+ | ==Background== |
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− | * Cytosine nucleotide analogue that inhibits DNA polymerase in [[human herpesviruses]] |
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+ | *Acyclic nucleoside phosphonate that competes with cytosine nucleotides to inhibit viral DNA polymerase |
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− | [[Category:Antivirals]] |
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+ | ===Spectrum of Activity=== |
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+ | *Active against essentially all [[:Category:DNA viruses|DNA viruses]], including polyomaviruses ([[BK virus]], [[JC virus]]), [[human papillomavirus]], [[adenovirus]], all of the [[human herpesviruses]], poxviruses (including [[monkeypox virus]] and [[variola virus]]) |
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+ | *Not active against h[[Hepatitis B virus|epatitis B virus]] or [[:Category:RNA viruses|RNA viruses]] |
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+ | ===Pharmacokinetics and Pharmacodynamics=== |
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+ | *Does not penetrate CSF |
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+ | ==Dosing== |
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+ | ==Safety== |
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+ | **Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria) |
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+ | *[[Neutropenia]] |
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+ | *Acute [[iritis]] |
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+ | [[Category:Acyclic nucleoside phosphonates]] |
Latest revision as of 19:14, 14 September 2020
Background
- Acyclic nucleoside phosphonate that competes with cytosine nucleotides to inhibit viral DNA polymerase
- Indications: Adenovirus, CMV after solid organ transplantation, Cytomegalovirus, Herpes simplex virus
Spectrum of Activity
- Active against essentially all DNA viruses, including polyomaviruses (BK virus, JC virus), human papillomavirus, adenovirus, all of the human herpesviruses, poxviruses (including monkeypox virus and variola virus)
- Not active against hepatitis B virus or RNA viruses
Pharmacokinetics and Pharmacodynamics
- Unlike ganciclovir, it does not need phosphorylation by UL97
- Does not penetrate CSF
Dosing
- Should be given with probenecid 2 g IV prior to each dose
Safety
- Major adverse effect is dose-dependent, irreversible renal tubular necrosis, which may be prevented by probenecid
- Contraindicated when creatinine >132 μmol/L, CrCl <55 mL/min, or urine protein ≥100 mg/dL (2+ proteinuria)
- Neutropenia
- Acute iritis