Chronic myeloid leukemia

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Clinical Presentation

  • Triphasic: chronic phase, accelerated phase, and blast crisis
  • Almost half are asymptomatic on diagnosis
  • Prsenting complaints may include fatigue, weight loss, sweating, abdominal fullness, and bleeding
  • Often have splenomegaly, which can contribute to the abdominal fullness and cause LUQ or left shoulder pain
  • Can present with anemia, very elevated WBCs, and elevated platelets