Chlamydia trachomatis: Difference between revisions
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Chlamydia trachomatis
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== Microbiology == |
== Microbiology == |
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* Two forms exist: |
* Two forms exist: |
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** '''Elementary body (EB):''' spore-like form than can survive short times outside the body |
** '''Elementary body (EB):''' spore-like form than can survive short times outside the body |
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** '''Reticulate body (RB):''' replicative form |
** '''Reticulate body (RB):''' replicative form |
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− | * Virulence factors |
+ | * Virulence factors include lipopolysaccharide (LPS) |
− | ** LPS |
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== Clinical Presentations == |
== Clinical Presentations == |
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* Presentation varies by serovar |
* Presentation varies by serovar |
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+ | {| class="wikitable" |
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− | {| |
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− | ! Syndrome |
+ | ! Syndrome !! Serovars |
− | ! Serovars |
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− | | Urethritis, PID, neonatal infection |
+ | | Urethritis, PID, neonatal infection || D to K |
− | | D to K |
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− | | Trachoma (chronic conjunctivitis) |
+ | | Trachoma (chronic conjunctivitis) || A to C |
− | | A to C |
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− | | Lymphogranuloma venereum (LGV) |
+ | | Lymphogranuloma venereum (LGV) || L1 to L3 |
− | | L1 to L3 |
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=== Urethritis === |
=== Urethritis === |
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* In men, most are symptomatic |
* In men, most are symptomatic |
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** Incubation or 7 to 21 days in men |
** Incubation or 7 to 21 days in men |
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=== Fitz-Hugh-Curtis syndrome === |
=== Fitz-Hugh-Curtis syndrome === |
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* Inflammatory ?autoimmune liver capsular inflammation |
* Inflammatory ?autoimmune liver capsular inflammation |
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== Diagnosis == |
== Diagnosis == |
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* Urine NAAT ~80% sensitive |
* Urine NAAT ~80% sensitive |
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* Self-collected vaginal swab better |
* Self-collected vaginal swab better |
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== Management == |
== Management == |
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* For serovars L1-L3 (LGV): treat for 21 days |
* For serovars L1-L3 (LGV): treat for 21 days |
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− | * In pregnant women, azithromycin is best |
+ | * In pregnant women, [[Is treated by::azithromycin]] is best |
− | {{DISPLAYTITLE:''Chlamydia'' |
+ | {{DISPLAYTITLE:''Chlamydia trachomatis''}} |
[[Category:Bacteria]] |
[[Category:Bacteria]] |
Revision as of 17:36, 11 November 2019
Microbiology
- Small, obligate intracellular Gram-negative coccobacillus
- Very difficult to Gram stain due to lack of peptidoglycan in cell wall
- Two forms exist:
- Elementary body (EB): spore-like form than can survive short times outside the body
- Reticulate body (RB): replicative form
- Virulence factors include lipopolysaccharide (LPS)
Clinical Presentations
- Presentation varies by serovar
Syndrome | Serovars |
---|---|
Urethritis, PID, neonatal infection | D to K |
Trachoma (chronic conjunctivitis) | A to C |
Lymphogranuloma venereum (LGV) | L1 to L3 |
Urethritis
- In men, most are symptomatic
- Incubation or 7 to 21 days in men
- Purulent urethritis
- In women, often asymptomatic
Fitz-Hugh-Curtis syndrome
- Inflammatory ?autoimmune liver capsular inflammation
Diagnosis
- Urine NAAT ~80% sensitive
- Self-collected vaginal swab better
- MD-collected cervical swab best (90+%)
- No more serology!
Management
- For serovars L1-L3 (LGV): treat for 21 days
- In pregnant women, azithromycin is best