Chlamydia trachomatis: Difference between revisions
From IDWiki
Chlamydia trachomatis
mNo edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
− | = Microbiology = |
+ | == Microbiology == |
* Small obligate intracellular Gram-negative coccobacillary organisms |
* Small obligate intracellular Gram-negative coccobacillary organisms |
||
Line 9: | Line 9: | ||
** LPS |
** LPS |
||
− | = Clinical Presentations = |
+ | == Clinical Presentations == |
* Presentation varies by serovar |
* Presentation varies by serovar |
||
Line 27: | Line 27: | ||
|} |
|} |
||
− | == Urethritis == |
+ | === Urethritis === |
* In men, most are symptomatic |
* In men, most are symptomatic |
||
Line 34: | Line 34: | ||
* In women, often asymptomatic |
* In women, often asymptomatic |
||
− | == Fitz-Hugh-Curtis syndrome == |
+ | === Fitz-Hugh-Curtis syndrome === |
* Inflammatory ?autoimmune liver capsular inflammation |
* Inflammatory ?autoimmune liver capsular inflammation |
||
− | = Diagnosis = |
+ | == Diagnosis == |
* Urine NAAT ~80% sensitive |
* Urine NAAT ~80% sensitive |
||
Line 45: | Line 45: | ||
* No more serology! |
* No more serology! |
||
− | = Management = |
+ | == Management == |
* For serovars L1-L3 (LGV): treat for 21 days |
* For serovars L1-L3 (LGV): treat for 21 days |
Revision as of 20:04, 15 August 2019
Microbiology
- Small obligate intracellular Gram-negative coccobacillary organisms
- Very difficult to gram stain due to lack of peptidoglycan in cell wall
- Two forms exist:
- Elementary body (EB): spore-like form than can survive short times outside the body
- Reticulate body (RB): replicative form
- Virulence factors
- LPS
Clinical Presentations
- Presentation varies by serovar
Syndrome | Serovars |
---|---|
Urethritis, PID, neonatal infection | D to K |
Trachoma (chronic conjunctivitis) | A to C |
Lymphogranuloma venereum (LGV) | L1 to L3 |
Urethritis
- In men, most are symptomatic
- Incubation or 7 to 21 days in men
- Purulent urethritis
- In women, often asymptomatic
Fitz-Hugh-Curtis syndrome
- Inflammatory ?autoimmune liver capsular inflammation
Diagnosis
- Urine NAAT ~80% sensitive
- Self-collected vaginal swab better
- MD-collected cervical swab best (90+%)
- No more serology!
Management
- For serovars L1-L3 (LGV): treat for 21 days
- In pregnant women, azithromycin is best