Ceftobiprole

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Background

Mechanism of Action

Binds to and inhibits PBP-2a on MRSA
Binds to and inhibits PBP-2x on penicillin-resistant Streptococcus pneumoniae

Spectrum of Activity

Active against MRSA, ampicillin-susceptible Enterococcus, and penicillin-resistant Streptococcus pneumoniae, as well as aerobic Gram-negative bacteria similar to other third-generation cephalosporins
Not active against Pseudomonas, ESBL-producers, or AmpC-producers

Dosing

Ceftobiprole 500 mg IV q8h over 2 hours

Safety

Adverse Drug Reactions

Nausea, diarrhea, neutropenia (4%), dysgeusia

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Cephalosporins