Ceftazidime-avibactam

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Background

  • Brand name Avycaz

Mechanism of Action

  • Ceftazidime is a third-generation cephalosporin
  • Avibactam
    • Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
    • No activity against class B
    • Reduces MIC to ceftazidime in most Enterobacterales including Pseudomonas
    • Does not induce AmpC expression
    • Slowly-reversible inhibitor that gets recycled

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • Short half-life 2.7 hours
  • Low protein binding
  • Primarily renally cleared

Dosing

Pediatric Dosing

  • 3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours
  • 6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours