Ceftazidime-avibactam: Difference between revisions
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(Created page with "== Background == * Brand name Avycaz === Mechanism of Action === * Ceftazidime is a third-generation cephalosporin * Avibactam ** Inhibitis class A, C, and some cla...") |
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− | == |
+ | ==Background== |
− | * |
+ | *Brand name Avycaz |
− | === |
+ | ===Mechanism of Action=== |
− | * |
+ | *[[Ceftazidime]] is a third-generation cephalosporin |
− | * |
+ | *[[Avibactam]] |
− | ** |
+ | **Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48 |
− | ** |
+ | **No activity against class B |
− | ** |
+ | **Reduces MIC to ceftazidime in most Enterobacterales including [[Pseudomonas]] |
− | ** |
+ | **Does not induce AmpC expression |
− | ** |
+ | **Slowly-reversible inhibitor that gets recycld |
− | === |
+ | ===Spectrum of Activity=== |
− | * |
+ | *GNBs |
− | ** |
+ | **Active against carbapenem resistant [[Enterobaceriaceaea]], including KPCs and AmpC lactamases- |
− | ** |
+ | **Restores activity with cefatzidime in [[Pseudomonas]] and other GNBs |
− | ** |
+ | **Poor activity against [[Acinetobacter]] and [[Stenotrophomonas]] |
+ | ===Pharmacokinetics and Pharmacodynamics=== |
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⚫ | |||
− | * |
+ | *Short half-life 2.7 hours |
− | * |
+ | *Low protein binding |
− | * |
+ | *Primarily renally cleared |
+ | |||
⚫ | |||
+ | |||
+ | * Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours |
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+ | |||
+ | === Pediatric Dosing === |
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+ | |||
+ | * 3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours |
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+ | * 6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours |
Revision as of 09:37, 12 September 2020
Background
- Brand name Avycaz
Mechanism of Action
- Ceftazidime is a third-generation cephalosporin
- Avibactam
- Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
- No activity against class B
- Reduces MIC to ceftazidime in most Enterobacterales including Pseudomonas
- Does not induce AmpC expression
- Slowly-reversible inhibitor that gets recycld
Spectrum of Activity
- GNBs
- Active against carbapenem resistant Enterobaceriaceaea, including KPCs and AmpC lactamases-
- Restores activity with cefatzidime in Pseudomonas and other GNBs
- Poor activity against Acinetobacter and Stenotrophomonas
Pharmacokinetics and Pharmacodynamics
- Short half-life 2.7 hours
- Low protein binding
- Primarily renally cleared
Dosing
- Ceftazidime-avibactam 2.5 g (2 g / 0.5 g) IV q8h, infused over 2 hours
Pediatric Dosing
- 3 months to <6 months: ceftazidime 40 mg/kg plus avibactam 10 mg/kg IV q8h, infused over 2 hours
- 6 months to <18 years: ceftazidime 50 mg/kg plus avibactam 12.5 mg/kg IV q8h, infused over 2 hours