Ceftazidime-avibactam: Difference between revisions
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Revision as of 09:29, 26 August 2020
Background
- Brand name Avycaz
Mechanism of Action
- Ceftazidime is a third-generation cephalosporin
- Avibactam
- Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
- No activity against class B
- Reduces MIC to ceftazidime in most Enterobacterales including Pseudomonas
- Does not induce AmpC expression
- Slowly-reversible inhibitor that gets recycld
Spectrum of Activity
- GNBs
- Active against carbapenem resistant Enterobaceriaceaea, including KPCs and AmpC lactamases-
- Restores activity with cefatzidime in Pseudomonas and other GNBs
- Poor activity against Acinetobacter and Stenotrophomonas
PK/PD
- Short half-life 2.7 hours
- Low protein binding
- Primarily renally cleared
