Ceftaroline: Difference between revisions
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+ | ==Background== |
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+ | ===Mechanism of Action=== |
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+ | *Binds to and inhibits PBP-2a |
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+ | ===Spectrum of Activity=== |
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+ | *Active against [[MRSA]], [[Staphylococcus epidermidis]], aerobic Gram-negative bacilli (similar to [[ceftriaxone]]) |
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+ | *Low to moderate activity against [[Enterococcus]] |
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+ | *Not active against [[Pseudomonas]], ESBL-producers, or AmpC-producers |
| + | === Pharmacokinetics and Pharmacodynamics === |
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| − | == Dosing == |
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| + | * Crosses in CSF adequately |
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+ | ==Dosing== |
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| + | ==Safety== |
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[[Category:Cephalosporins]] |
[[Category:Cephalosporins]] |
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Latest revision as of 22:15, 26 January 2022
Background
Mechanism of Action
- Binds to and inhibits PBP-2a
Spectrum of Activity
- Active against MRSA, Staphylococcus epidermidis, aerobic Gram-negative bacilli (similar to ceftriaxone)
- Low to moderate activity against Enterococcus
- Not active against Pseudomonas, ESBL-producers, or AmpC-producers
Pharmacokinetics and Pharmacodynamics
- Crosses in CSF adequately
Dosing
- SSTI: ceftaroline 600 mg IV q12h
- Pneumonia and bacteremia: ceftaroline 600 mg IV q8h
Safety
Adverse Drug Reactions
- Rash, eosinophilia, reversible neutropenia (20% when ≥3 weeks)
