Cefiderocol: Difference between revisions
From IDWiki
(Created page with "== Background == === Mechanism of Activity === * Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin === Spectrum of Activity === * Acti...") |
No edit summary |
||
| Line 1: | Line 1: | ||
| − | == |
+ | ==Background== |
| − | === |
+ | ===Mechanism of Activity=== |
| − | * |
+ | *Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin |
| − | === |
+ | ===Spectrum of Activity=== |
| − | * |
+ | *Active against all Ambler class beta-lactamases, including carbapenemases |
| − | * |
+ | *Active against [[Acinetobacter]], [[Enterobacterales]], [[Pseudomonas]], [[Burkholderia]], and [[Stenotrophomonas]] |
| − | * |
+ | *Not active against Gram-positive bacteria |
| + | |||
| + | == Dosing == |
||
| + | |||
| + | * Cefiderocol 2 g IV q8h, infused over 3 hours |
||
| + | |||
| + | [[Category:Siderophore cephalosporins]] |
||
Revision as of 09:34, 12 September 2020
Background
Mechanism of Activity
- Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin
Spectrum of Activity
- Active against all Ambler class beta-lactamases, including carbapenemases
- Active against Acinetobacter, Enterobacterales, Pseudomonas, Burkholderia, and Stenotrophomonas
- Not active against Gram-positive bacteria
Dosing
- Cefiderocol 2 g IV q8h, infused over 3 hours
