Cefazolin: Difference between revisions
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(Created page with "== Background == === Clinical Breakpoints === {| class="wikitable" ! rowspan="2" |Species ! rowspan="2" |ECV (μg/mL) ! colspan="3" |Breakpoints (μg/mL) ! colspan="3" |Break...") |
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| + | == Dosing == |
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| + | |||
| + | * Low dose (for UTI or uncomplicated soft tissue infection): 1 g IV with |
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| + | * Standard dose: 2 h IV q8h |
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| + | * High dose (for critical illness and IE): 2 f IV q6h |
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| + | |||
| + | === Renal Dosing === |
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| + | |||
| + | {| class="wikitable" |
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| + | ! eGFR (mL/min) |
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| + | ! Standard Dose |
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| + | ! High Dose |
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| + | |- |
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| + | | >40 |
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| + | | |
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| + | | |
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| + | |- |
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| + | | 20-40 |
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| + | | 2 g IV q12h |
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| + | | 2 h IV q12h |
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| + | |- |
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| + | | <20 |
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| + | | 1 g IV q24h |
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| + | | 1 g IV q24h |
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| + | |- |
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| + | | CRRT |
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| + | | 2 h IV q12h |
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| + | | 2 h IV q12h |
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| + | |} |
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| + | |||
| + | |||
[[Category:Cephalosporins]] |
[[Category:Cephalosporins]] |
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Latest revision as of 15:20, 30 August 2022
Background
Clinical Breakpoints
| Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||
|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||
| Enterobacteriaceae (systemic) | ≤2 | 4 | ≥8 | ||||
| Enterobacteriaceae (urinary) | ≤16 | ≥32 | |||||
Dosing
- Low dose (for UTI or uncomplicated soft tissue infection): 1 g IV with
- Standard dose: 2 h IV q8h
- High dose (for critical illness and IE): 2 f IV q6h
Renal Dosing
| eGFR (mL/min) | Standard Dose | High Dose |
|---|---|---|
| >40 | ||
| 20-40 | 2 g IV q12h | 2 h IV q12h |
| <20 | 1 g IV q24h | 1 g IV q24h |
| CRRT | 2 h IV q12h | 2 h IV q12h |
