CMV in HIV patients

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Revision as of 09:26, 21 July 2022 by Aidan (talk | contribs) (Created page with "==Clinical Manifestations== ===Gastrointestinal Disease=== * Esophagitis, with odynophagia, fever, nausea, retrosternal burning * Gastritis, with retrosternal and epigastric burning, rarely GI bleed * Enteritis, with abdominal pain and diarrhea * Colitis (most common end-organ disease after retinitis, with fever, weight loss, anorexia, malaise, and abdominal pain ** Sporadic, explosive watery diarrhea ** May have tenesmus and hematochezi...")
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Clinical Manifestations

Gastrointestinal Disease

  • Esophagitis, with odynophagia, fever, nausea, retrosternal burning
  • Gastritis, with retrosternal and epigastric burning, rarely GI bleed
  • Enteritis, with abdominal pain and diarrhea
  • Colitis (most common end-organ disease after retinitis, with fever, weight loss, anorexia, malaise, and abdominal pain
    • Sporadic, explosive watery diarrhea
    • May have tenesmus and hematochezia
  • Can also affect oropharynx and anus, with superficial painful ulcers

Retinitis

Management

  • All patients should be started on ART
  • Ganciclovir 5 mg/kg q12h for 3 to 6 weeks of induction therapy, and until symptoms resolve
    • Once tolerating oral therapy, or if disease is mild, can use valganciclovir 900 mg PO bid
  • Maintenance valganciclovir should be continued in patients with CMV retinitis or if there is a relapse after induction
  • The alternative agent for induction if foscarnet 60 mg/kg q8h or 90 mg/kg q12h