Angioimmunoblastic T-cell lymphoma: Difference between revisions
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(Created page with "== Background == * Subtype of mature peripheral T-cell lymphoma * Previously also known as angioimmunoblastic lymphadenopathy with dysproteinemia, immunoblastic lymphadenopathy, and lymphogranulomatosis X * Accounts for 1 to 2% of non-Hodgkin lymphoma * Derives from follicular T helper (T<sub>FH</sub>) cells == Clinical Manifestations == * Myriad and often non-specific, resulting in delayed diagnoses * Usually advanced stage at diagnosis * Most common symptoms are...") |
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* May have hypereosinophilia, occasionally have thrombocytopenia |
* May have hypereosinophilia, occasionally have thrombocytopenia |
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* May have false-positive autoimmune tests, including rheumatoid factor and anti-smooth muscle antibodies |
* May have false-positive autoimmune tests, including rheumatoid factor and anti-smooth muscle antibodies |
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| + | === Prognosis === |
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| + | * 5-year survival about 30% |
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| + | == Further Reading == |
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| + | * Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma. ''Blood''. 2017;129(9):1095-1102. doi: [https://doi.org/10.1182/blood-2016-09-692541 10.1182/blood-2016-09-692541] |
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[[Category:Hematology]] |
[[Category:Hematology]] |
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Latest revision as of 22:30, 9 October 2022
Background
- Subtype of mature peripheral T-cell lymphoma
- Previously also known as angioimmunoblastic lymphadenopathy with dysproteinemia, immunoblastic lymphadenopathy, and lymphogranulomatosis X
- Accounts for 1 to 2% of non-Hodgkin lymphoma
- Derives from follicular T helper (TFH) cells
Clinical Manifestations
- Myriad and often non-specific, resulting in delayed diagnoses
- Usually advanced stage at diagnosis
- Most common symptoms are constitutional symptoms (fevers, night sweats, weight loss) and lymphadenopathy
- May have hepatosplenomegaly
- May have skin lesions which range from urticaria to nodules
- May get rash after antibiotics
- Often have elevated LDH, anemia, positive DAT, hypergammaglobulinemia (polyclonal)
- May have hypereosinophilia, occasionally have thrombocytopenia
- May have false-positive autoimmune tests, including rheumatoid factor and anti-smooth muscle antibodies
Prognosis
- 5-year survival about 30%
Further Reading
- Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma. Blood. 2017;129(9):1095-1102. doi: 10.1182/blood-2016-09-692541
