Adenovirus: Difference between revisions

Revision as of 10:40, 13 August 2020

Background

Microbiology

Non-enveloped double-stranded DNA virus
Seven species with multiple serotypes

Epidemiology

Transmitted by droplets or aerosol

Clinical Manifestations

Common cause of upper respiratory infections (colds) in immunocompetent people
Can also cause pharyngitis, pharyngoconjunctival fever, epidemic keratoconjunctivitis, acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
In cellular immunodeficiency or neonates, can cause severe disease
- Disseminated disease
- Hemorrhagic cystitis in hematopoietic stem cell transplant patients and children

Diagnosis

Typically by PCR
May see smudge cells on histology (but not specific)

Management

Usually treated supportively
Only current effective treatment is cidofovir, indicated in severe or life-threatening disease

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
-* Non-enveloped double-stranded DNA virus
-* Seven species with multiple serotypes
+*Non-enveloped double-stranded DNA virus
-=== Epidemiology ===
+*Seven species with multiple serotypes
-* Transmitted by droplets or aerosol
+===Epidemiology===
-== Clinical Manifestations ==
-* Common cause of upper respiratory infections in immunocompetent people
-* Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
-* In cellular immunodeficiency or neonates, can cause severe disease
-** Disseminated disease
-** Hemorrhagic cystitis in hematopoietic stem cell transplant
+*Transmitted by droplets or aerosol
-== Diagnosis ==
-* Typically by PCR
-* May see smudge cells on histology (but not specific)
+==Clinical Manifestations==
-== Management ==
-* Only current effective treatment is [[Is treated by::cidofovir]]
+*Common cause of upper respiratory infections (colds) in immunocompetent people
+*Can also cause [[pharyngitis]], pharyngoconjunctival fever, epidemic [[keratoconjunctivitis]], acute hemorrhagic [[conjunctivitis]], [[hepatitis]], [[urethritis]] or [[Genital ulcer disease|genital ulcers]] (sexually-transmitted)
+*In cellular immunodeficiency or neonates, can cause severe disease
+**Disseminated disease
+**[[Hemorrhagic cystitis]] in hematopoietic stem cell transplant patients and children
+==Diagnosis==
+*Typically by PCR
+*May see smudge cells on histology (but not specific)
+==Management==
+*Usually treated supportively
+*Only current effective treatment is [[Is treated by::cidofovir]], indicated in severe or life-threatening disease
 [[Category:Adenoviridae]]