Adenovirus: Difference between revisions
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== Background == |
== Background == |
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=== Microbiology === |
=== Microbiology === |
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| − | * |
+ | * Non-enveloped double-stranded DNA virus |
| + | * Seven species with multiple serotypes |
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| + | |||
| + | === Epidemiology === |
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| + | * Transmitted by droplets or aerosol |
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== Clinical Presentation == |
== Clinical Presentation == |
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* Common cause of upper respiratory infections in immunocompetent people |
* Common cause of upper respiratory infections in immunocompetent people |
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| + | * Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted) |
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| − | * In cellular immunodeficiency, can cause severe disease |
+ | * In cellular immunodeficiency or neonates, can cause severe disease |
| + | ** Disseminated disease |
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| + | ** Hemorrhagic cystitis in hematopoietic stem cell transplant |
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| + | |||
| + | == Diagnosis == |
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| + | * Typically by PCR |
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| + | * May see smudge cells on histology (but not specific) |
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== Management == |
== Management == |
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Revision as of 17:04, 27 January 2020
Background
Microbiology
- Non-enveloped double-stranded DNA virus
- Seven species with multiple serotypes
Epidemiology
- Transmitted by droplets or aerosol
Clinical Presentation
- Common cause of upper respiratory infections in immunocompetent people
- Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
- In cellular immunodeficiency or neonates, can cause severe disease
- Disseminated disease
- Hemorrhagic cystitis in hematopoietic stem cell transplant
Diagnosis
- Typically by PCR
- May see smudge cells on histology (but not specific)
Management
- Only current effective treatment is cidofovir
