Acute toxic leukoencephalopathy

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Background

Etiologies

Chemotherapy
Heroin use
Opioid use
Immunsuppression
Imidazole
Crack cocaine use
Environmental (carbon monoxide)
Ethanol
Splenial lesions from antiseizure, chemotherapeutic, or immunosuppressive medications

Differential Diagnosis

Anoxic-ischemic brain injury
Alcohol use disorder, including associated with cirrhosis and Wernicke encephalopathy
Chronic toluene use (glue sniffing)

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Neurology