AIDS cholangiopathy
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Revision as of 10:47, 13 July 2022 by Aidan (talk | contribs) (Created page with "==Background== * Biliary obstructive from infection-related strictures of the biliary tract in the context of advanced HIV infection ===Etiologies=== * Cryptosporidium parvum (most common) * CMV (second-most common) * Others: Microsporidium, Cyclospora cayetanensis, Isospora, Giardia, Histoplasma * Idiopathic (also common) ===Risk Factors=== * Much more common with CD4 less than 100 ==Clinical Manifestations== * Right upper quadrant pai...")
Background
- Biliary obstructive from infection-related strictures of the biliary tract in the context of advanced HIV infection
Etiologies
- Cryptosporidium parvum (most common)
- CMV (second-most common)
- Others: Microsporidium, Cyclospora cayetanensis, Isospora, Giardia, Histoplasma
- Idiopathic (also common)
Risk Factors
- Much more common with CD4 less than 100
Clinical Manifestations
- Right upper quadrant pain
- Elevated cholestatic liver enzymes (ALP of 700-800), often with normal ALT and bilirubin
- May have fever and jaundice
- Can result in sclerosing cholangitis and liver failure
