Antistreptolysin O
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Revision as of 17:30, 5 May 2023 by Aidan (talk | contribs) (Created page with "* Detects prior infection with or exposure to Streptococcus pyogenes *Used most often for diagnosis of acute rheumatic fever, and far less useful for streptococcal pharyngitis and post-streptococcal glomerulonephritis *Starts increasing around 1 week after infection, peaking at 3 to 6 weeks, then decreasing thereafter **Rate of decrease is not related to clinical course *False negatives: **Sample collected during latency period **Sample collected late in...")
- Detects prior infection with or exposure to Streptococcus pyogenes
- Used most often for diagnosis of acute rheumatic fever, and far less useful for streptococcal pharyngitis and post-streptococcal glomerulonephritis
- Starts increasing around 1 week after infection, peaking at 3 to 6 weeks, then decreasing thereafter
- Rate of decrease is not related to clinical course
- False negatives:
- Sample collected during latency period
- Sample collected late in convalescence
- Post-pyoderma (e.g. post-streptococcal glomerulonephritis)
- Corticosteroids and other immunosuppression
- Early administration of antibiotics
- False positives:
- Infection with Group C and Group G streptococci
- Lipemic sample
- Bacterial contamination of sample
- Non-specific normal antibodies
- Tuberculosis
- Active viral hepatitis
- Monoclonal gammopathy
Further Reading
- The clinical-diagnostic role of antistreptolysin O antibodies. Acta Clin Belg. 2011;66(6):410-5. doi: 10.2143/ACB.66.6.2062604. PMID: 22338301.
