Complement deficiency
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Revision as of 16:55, 24 February 2023 by Aidan (talk | contribs) (Created page with "== Background == * Group of primary or acquired immunodeficiencies affecting the complement system within the innate humoural immune system * Usually autosomal recessive genetic diseases * Commonly defined as early (C1-C4) or late (C5-C9) == Clinical Manifestations == {| class="wikitable" !Deficiency ! |- |Early (C1, C2, and C4) |Encapsulated bacterial infections like Streptococcus pneumoniae and Haemophilus influenzae type b. Higher risk...")
Background
- Group of primary or acquired immunodeficiencies affecting the complement system within the innate humoural immune system
- Usually autosomal recessive genetic diseases
- Commonly defined as early (C1-C4) or late (C5-C9)
Clinical Manifestations
| Deficiency | |
|---|---|
| Early (C1, C2, and C4) | Encapsulated bacterial infections like Streptococcus pneumoniae and Haemophilus influenzae type b. Higher risk of autoimmune diseases, particularly systemic lupus erythematosus) |
| Early (C3) | Ssevere recurrent pyogenic infections early in life |
| Late (C5-C9) | Recurrent Neisseria infections |
| Alternative (properdin) | Recurrent Neisseria infections |
| Mannan-binding lectin | Increase frequency of pyogenic infections, particularly in young children |
