Gardnerella vaginalis

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Gardnerella vaginalis /
Revision as of 16:05, 11 January 2023 by Aidan (talk | contribs) (Created page with "{{DISPLAYTITLE:''Gardnerella vaginalis''}} == Background == * Gram-negative bacillus == Clinical Manifestations == * Involved in bacterial vaginosis, a dysbiosis rather than infection * Rare cause of other infections, including urinary tract infection == Management == * Bacterial vaginosis (a dysbiosis rather than infection) is usually treated with metronidazole, which helps to normalize the overall vaginal microbiome rather than treating the ''Gardnere...")
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Background

  • Gram-negative bacillus

Clinical Manifestations

  • Involved in bacterial vaginosis, a dysbiosis rather than infection
  • Rare cause of other infections, including urinary tract infection

Management

  • Bacterial vaginosis (a dysbiosis rather than infection) is usually treated with metronidazole, which helps to normalize the overall vaginal microbiome rather than treating the Gardnerella
  • Very little information about antibiotic susceptibility that would be relevant for treating infections
    • Based on one Brazilian study, ampicillin/sulbactam, clindamycin, chloramphenicol are likely reliable; ampicillin and metronidazole are not[1]
    • A case series reports treatment with ceftriaxone, cefuroxime, aminoglycosides, metronidazole, ciprofloxacin[2]
  1. Knupp de Souza DM, Diniz CG, Filho DSC, Andrade de Oliveira LM, Coelho DM, Talha L de S, Nascimento TC do, Ferreira-Machado AB, Silva VL da (2016) Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women. J Infect Dev Ctries 10:913–919. doi: 10.3855/jidc.7161
  2. Christine M Akamine, Andrew Chou, Shahriar Tavakoli-Tabasi, Daniel M Musher, Gardnerella vaginalis Bacteremia in Male Patients: A Case Series and Review of the Literature, Open Forum Infectious Diseases, Volume 9, Issue 10, October 2022, ofac176, doi: 10.1093/ofid/ofac176