Coagulase-negative staphylococci

• Group of Gram-positive cocci that are catalase positive and coagulase negative

Organisms

• Staphylococcus epidermidis group
  • Staphylococcus epidermidis
  • Staphylococcus capitis
  • Staphylococcus simulans
• Staphylococcus haemolyticus group
  • Staphylococcus haemolyticus
  • Staphylococcus hominis
  • Staphylococcus devriesei
• Staphylococcus saprophyticus: mainly causes UTIs
• Staphylococcus massiliensis
• Staphylococcus lugdenensis: has more in common with Staphylococcus aureus and should never be considered a contaminant
• Unclear grouping
  • Staphylococcus lyticans
  • Staphylococcus pettenkoferi
  • Staphylococcus petrasii
  • Staphylococcus pseudolugdunensis
  • Staphylococcus warneri

Management

• Generally resistant to β-lactams
• First-line: vancomycin
• Alternatives: linezolid, daptomycin, co-trimoxazole, ciprofloxacin, doxycycline