Thromboangiitis obliterans
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Revision as of 13:47, 12 July 2022 by Aidan (talk | contribs) (Created page with "== Differential Diagnosis == * Peripheral artery disease * Thromboembolism * Vasculitis * Trauma * Medication effects, including amphetamines and cocaine == Diagnosis == === Clinical Criteria === * Criteria are not universally accepted but include ** Age less than 50 years (or 45 years) ** Current or recent tobacco use ** Ischemia of the distal extremities, documented by vascular testing ** Typical arteriographic findings, including corksc...")
Differential Diagnosis
- Peripheral artery disease
- Thromboembolism
- Vasculitis
- Trauma
- Medication effects, including amphetamines and cocaine
Diagnosis
Clinical Criteria
- Criteria are not universally accepted but include
- Age less than 50 years (or 45 years)
- Current or recent tobacco use
- Ischemia of the distal extremities, documented by vascular testing
- Typical arteriographic findings, including corkscrew appearance, spider legs, or tree roots
- Exclusion of other causes, including autoimmune diseases, thrombophilia, diabetes mellitus, and thromboembolism
Investigations
- CBC, liver panel, electrolytes, cretinine, HbA1c, lipid panel, urinalysis
- ESR/CRP
- ANA, RF, cryoglobulins, complements, anti-centromere (for CREST), anti-Scl-70 (for scleroderma), antiphospholipid antibodies
- Protein C & S, antithrombin III, Factor V Leiden, prothrombin, homocysteinemia
- Toxicology for cocaine and amphetamines
- Ultrasound with segmental arterial Dopplers
- Echocardiography (for embolic source)
- +/- CT (for embolic source)
- Biopsy, maybe
