Azacitidine

• Cytidine analogue used to treat myelodysplastic syndrome and acute myelogenous leukemia
• Can cause cytopenias and hepatotoxicity and renal toxicity
• Infectious complications include febrile neutropenia
• Bacterial infections are common, including pneumonia, URTI, cellulitis, bacteremia, urinary tract infections, intraabdominal infections (in descending order of frequency)1
  • Viral infections and fungal infections (including invasive aspergillosis) are also possible complications