Febrile non-hemolytic transfusion reaction
From IDWiki
Background
- Common transfusion reaction, occuring with about 1 in 300 RBCs and 1 in 20 pooled platelets
- Caused by transfusion of cytokines along with the blood product, or by recipient antibodies to WBCs or platelets in the transfused blood product
Clinical Manifestations
- Fever during or up to 4 hours after transfusion
- May have chills, rigors, nausea, vomiting, or hypotension
Management
- Acetaminophen 325 to 650 mg p.o.
- For severe rigors, meperidine 25 to 50 mg IV
- Can be prevented using premedication with acetaminophen and diphenhydramine
