Acute hemolytic transfusion reaction
From IDWiki
Background
- Caused by:
- Incompatibles RBCs (ABO or other blood group)
- Incompatible plasma
- Occurs in 1 in 38,000 transfusion, usually due to clerical error causing patient to receive wrong blood
- Mortality about 10%
Clinical Manifestations
- Fevers, chills, rigors, hemoglobinuria
- Fever may be only sign at presentation
- May have nausea, vomiting, pain at infusion site, flank pain, hypotension, AKI, or DIC
Management
- Stop transfusion and notify blood bank
- Send hemolysis workup with CBC, reticulocyte count, bilirubin, LDH, and haptoglobin
- Supportive care
