Exogenous lipoid pneumonia

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Background

  • Aspirated or inhaled fat or oil is engulfed by alveolar macrophages, which die and release the contained oil, resulting in inflammation, giant cell granulomatous reactions, and fibrosis

Clinical Manifestations

  • Presents as a non-resolving pneumonia associated with inhaled or aspirated oil
  • Cough, dyspnea, and fever, and occasionally weight loss, chest pain, and hemoptysis
  • May be acute following aspiration of a large amount of oil, or chronic with repeated exposures over time

Differential Diagnosis