Background
- Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria
Mechanism of Action
- Mechanism of action is to depolarize the cell membrane
Pharmacokinetics and Pharmacodynamics
- Bactericidal
- Distributes well into soft tissues and musculoskeletal system, as well as urine
- Poor CNS penetration
- Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia
