Ceftaroline
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Revision as of 10:34, 3 September 2020 by Aidan (talk | contribs) (Created page with "== Background == === Mechanism of Action === * Binds to and inhibits PBP-2a === Spectrum of Activity === * Active against MRSA, Staphylococcus epidermidis, aerobic...")
Background
Mechanism of Action
- Binds to and inhibits PBP-2a
Spectrum of Activity
- Active against MRSA, Staphylococcus epidermidis, aerobic Gram-negative bacilli
- Low to moderate activity against Enterococcus species
- Not active against Pseudomonas species, ESBL-producers, or AmpC-producers
Dosing
- SSTI: ceftaroline 600 mg IV q12h
- Pneumonia and bacteremia: ceftaroline 600 mg IV q8h
Safety
Adverse Drug Reactions
- Rash, eosinophilia, reversible neutropenia (20% when ≥3 weeks)
