Yellow fever vaccine-associated neurotropic disease

Background

Risk Factors

• Extremes of age (children <6 months and adults >60-70 years)

Pathophysiology

• Meningoencephalitis (neurotropic disease) is caused by actual infection with the attenuated virue
• The other syndromes are caused by autoimmune phenomena

Clinical Manifestations

• Includes meningoencephalitis (neurotropic disease), acute disseminated encephalomyelitis, Guillain-Barré syndrome, and acute bulbar palsy
• Incubation period is 7 to 21 days (range 4 to 23 days)
• Rarely fatal