Ceftazidime-avibactam

Background

• Brand name Avycaz

Mechanism of Action

• Ceftazidime is a third-generation cephalosporin
• Avibactam
  • Inhibitis class A, C, and some class D beta-lactamases, includign OXA-48
  • No activity against class B
  • Reduces MIC to ceftazidime in most Enterobacterales including Pseudomonas
  • Does not induce AmpC expression
  • Slowly-reversible inhibitor that gets recycld

Spectrum of Activity

• GNBs
  • Active against carbapenem resistant Enterobaceriaceaea, including KPCs and AmpC lactamases-
  • Restores activity with cefatzidime in Pseudomonas and other GNBs
  • Poor activity against Acinetobacter and Stenotrophomonas

PK/PD

• Short half-life 2.7 hours
• Low protein binding
• Primarily renally cleared