Background
- Oxazolidinone antibiotic
Mechanism of Action
- Inhibits the 50S ribosome of Gram-positive bacteria
Spectrum of Activity
- Active against Gram-positive bacteria
- Not active against Gram-negative bacteria
Dosing
- Linezolid 600 mg PO/IV q12h
Adverse Drug Reactions
- Serotonin syndrome when taken concurrently with certain psychiatric medications
- Ideally hold SSRIs when starting linezolid
- Cytopenias, including thrombocytopenia (most common), anemia, and leukopenia (least common)
- More common with prolonged use, e.g. after 2 weeks
