Central line-associated bloodstream infection
From IDWiki
Background
- For surveillance purposes, a CLABSI is essentially a bloodstream infection attributed to a catheter that was in place within 48 hours of blood culture
- Catheter-related bloodstream infection (CRBSI) is defined by the IDSA
- Confirmed
- Peripheral culture and catheter tip culture both positive for same organism
- Peripheral culture and catheter lumen culture both positive for same organism with either
- Quantitative cultures showing ≥3-fold higher CFU from the catheter
- Time-to-positivity of the catheter culture 2 hours earlier than that of the the peripheral
- Possible
- Quantitative cultures from two different lumens of the same catheter positive for the same organism with ≥3-fold difference in CFU between lumens
- Confirmed
Management
Short-term CVC or arterial line infection
- Uncomplicated: no other foci of infection, fever resolves promptly ≤72h, no other intravascular hardware, no evidence of endocarditis or suppurative thrombophlebitis, and (if S. aureus) no active malignancy or immunosuppression
- Coagulase-negative staphylococci: remove catheter and treat with antibiotic for 5-7 days; if catheter not removed, do lock therapy and treat for 10-14 days
- Staphylococcus aureus: remove catheter and treat with antibiotic for ≥14 days
- Enterococcus species: remove catheter and treat with antibiotic for 7-14 days
- Gram-negative bacillus: remove catheter and treat with antibiotic for 7-14 days
- Candida species: remove catheter and treat with antifungal for 14 days from first negative blood culture
- Complicated: anyone not meeting above definition of uncomplicated
- Remove catheter and treat with antimicrobial for 4-6 weeks, or for 6-8 weeks if osteomyelitis
Long-term CVC or port infection
- Definitions of complicated and uncomplicated are same as above
- Uncomplicated
- Coagulase-negative staphylococci: may retain and treat with lock therapy and antibiotic for 10-14 days; remove catheter if clinical deterioration or relapse
- Staphylococcus aureus: remove catheter and treat with antibiotic for 4-6 weeks (some exceptions apply)
- Enterococcus species: may retain and treat with lock therapy and antibiotic for 7-14 days; remove catheter if clinical deterioration or relapse
- Gram-negative bacillus: remove catheter and treat with antibiotic for 7-14 days; if attempting salvage, treat with lock therapy and antibiotic for 10-14 days and reassess
- Candida species: remove catheter and treat with antifungal for 14 days from first negative blood culture
Prevention
- Perform hand hygiene, use aseptic technique when manipulating catheter, use barrier precaution for insertion
- Remove catheters as soon as they are no longer needed
- Antimicrobial-impregnated catheters may be helpful
Further Reading
- Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update. Clin Infect Dis. 2009:49(1):1-45. doi: 10.1086/599376
References
- ^ Isaac See, Alison G. Freifeld, Shelley S. Magill. Causative Organisms and Associated Antimicrobial Resistance in Healthcare-Associated, Central Line–Associated Bloodstream Infections From Oncology Settings, 2009–2012. Clinical Infectious Diseases. 2016;62(10):1203-1209. doi:10.1093/cid/ciw113.
- ^ Michelle Gompelman, Carmen Paus, Ashley Bond, Reinier P Akkermans, Chantal P Bleeker-Rovers, Simon Lal, Geert JA Wanten. Comparing success rates in central venous catheter salvage for catheter-related bloodstream infections in adult patients on home parenteral nutrition: a systematic review and meta-analysis. The American Journal of Clinical Nutrition. 2021;114(3):1173-1188. doi:10.1093/ajcn/nqab164.
