Yellow fever vaccine-associated viscerotropic disease

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Background

Risk Factors

  • Risk increases with age > 60 years
  • Thymus disease (thymoma, myasthenia gravis, thymectomy)

Clinical Manifestations

  • Incubation period 2 to 5 days
  • Characterized by multiorgan failure similar to yellow fever
  • High mortality 65%, higher in women