Culture-negative endocarditis

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Organism Clinical clues Diagnostic tests
Brucella species unpasteurized dairy blood cultures, serology, culture, immunohistology, PCR
Coxiella burnetii animal exposure (especially pregnant sheep) serology (IgG phase I >1:800), tissue culture, immunohistology, PCR
Bartonella species cat exposure, louse exposure, crowding blood cultures, serology, culture, immunohistology, PCR
Tropheryma whipplei histology and PCR
Mycoplasma species serology, culture, immunohistology, PCR
Legionella species blood cultures, serology, culture, immunohistology, PCR
Fungi IV drug use, immunocompromise blood cultures, serology, PCR