Herpesviridae

Microbiology

• A family of double-stranded DNA viruses that cause disease in humans

Viruses

• Alphaherpesviruses: dormant in neurons
  • HHV-1: HSV-1
  • HHV-2: HSV-2
  • HHV-3: VZV
  • Also remember Macacine alphaherpesvirus 1
• Betaherpesviruses
  • HHV-5: CMV
  • HHV-6 and HHV-7: roseolaviruses
• Gammaherpesviruses: associated with malignancy
  • HHV-4: EBV
  • HHV-8: Kaposi sarcoma–associated herpesvirus

Management

• Typically respond to antivirals, including acyclovir, valacyclovir, ganciclovir, valganciclovir, and foscarnet