Galactomannan

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Galactomannan

Definition

  • Quantitative analysis of galactomannan levels in either bronchoalveolar lavage or blood that is used to diagnose invasive aspergillosis

Pathophysiology

  • Galactomannan is a component of the cell wall of Aspergillus species that is released when the organism is actively dividing

Interpretation

  • Bronchoalveolar lavage more sensitive than serum
  • False-positives in pip/tazo, amox/clav, Penicillium spp., Histoplasma spp.
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