Antibiotic prophylaxis for open fractures

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Gustilo Classification

  • Type I: open fracture with skin wound <1cm in length and clean
  • Type II: open fracture with a laceration >1cm in length without extensive soft tissue damage, flaps, or avulsions
  • Type III: open segmental fracture with >10cm wound with extensive soft tissue injury or a traumatic amputation
    • IIIA: adequate soft tissue coverage
      • All farm injuries and gunshots are automatically at least IIIA
    • IIIB: significant soft tissue loss with exposed bone that requires soft tissue transfer to achieve coverage
    • IIIC: associated vascular injury that requires repair for limb preservation
    • Special categories:
      • gunshot injuries
      • any open fracture caused by a farm injury
      • any open fracture with accompanying vascular injury requiring repair

Risk of Infection

  • Type I: 0%
  • Type II: 2%
  • Type III: 6-44%
    • Type IIIA: 2%
    • Type IIIB: 11%
    • Type IIIC: 20%

Management

  • Don't forget tetanus!
  • Antibiotic choice
    • Cover gram-negatives as soon as possible after injury
    • Add gram-negative coverage for type III fractures
    • At HGH: cefazolin, tobramycin, and metronidazole
    • Add high-dose penicillin to cover clostridium, in the presence of fecal contamination or farm-related injuries
    • Fluoroquinolones should be avoided, if possible, due to slowing bone healing
  • Duration
    • Continue for 24 hours after wound closure
    • If type III, continue for at least 72 hours post-injury if Type III

Further Reading

  • Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. *J Bone Joint Surg Am*. 1976 Jun;58(4):453-8.